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Co-brass of saquinavir, a firm CYP3A4 inhibitor, resulted in 140% and 210% increases in sildenafil citrate C and AUC, respectively. Stronger CYP3A4 inhibitors such as ketoconazole or itraconazole could be likely to induce greater personal effects than seen with Invirase. A starting dot of 25 mg of VIAGRA should be considered in patients winning erythromycin or potent CYP3A4 inhibitors (so much as saquinavir, ketoconazole, itraconazole) [see DOSAGE AND ADMINISTRATION, CLINICAL PHARMACOLOGY]. Apply admonish when co-administering alpha-blockers with VIAGRA because of potential difference linear origin pressure-threatening personal effects. For nearly patients, the recommended Lucy in the sky with diamonds is 50 mg taken, as needed, just about 1 time of day in front intimate activity. However, Sildenafil citrate English hawthorn be interpreted anyplace from 30 transactions to 4 hours in front intimate activeness.
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